Apr 19, 2023 · FDA approved a REMS for codeine to ensure that the benefits outweigh the risk. ... Tylenol, benzonatate, Benadryl, diphenhydramine, guaifenesin. Images. Codeine ... Apr 19, 2023 · Guaifenesin and Codeine Phosphate Oral Solution ( C-V) Robafen AC ( C-V) Major. 200 mg/5 mL Guaifenesin and Codeine Phosphate 8 mg/5 mL. Codar GF ( C-V) Respa. 200 mg/5 mL Guaifenesin and Codeine Phosphate 10 mg/5 mL. Coditussin AC ( C-V) Glendale. 225 mg/5 mL Guaifenesin and Codeine Phosphate 7.5 mg/5 mL. Mar-Cof CG ( C-V) Marnel CODEINE; GUAIFENESIN; PSEUDOEPHEDRINE (KOE deen; gwye FEN e sin; soo doe e FED rin) treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, loosening mucus, and decreasing a runny or stuffy nose. It is a combination of an opioid cough suppressant, an expectorant, and a decongestant.Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ...Store at controlled room temperature 15°-30°C (59°-86°F). Cherry Flavor, Citric Acid, Glycerin,Masking flavor, Propylene glycol, Purified Water, Sodium Citrate, Sodium Benzoate, Sucralose Sorbitol. NDC 58657-500-16 - Codeine-Guaifenesin Oral Solution - 10-100 mg/5 mL - Antitussive - Expectorant - 16 fl. oz ...alcohol while taking hydrocodone bitartrate and guaifenesin tablets because co-ingestion can result in fatal plasma hydrocodone levels. (5.8, 7.1) • Hydrocodone bitartrate and guaifenesin tablets is not recommended for use in pregnant women. Prolonged use of hydrocodone bitartrate and guaifenesin tablets during pregnancy can result in Jun 20, 2022 · Codeine is a natural opioid that has a long history for use in cough. However, studies of this indication show it is no more effective than placebo 3,4 and has been shown to cause dangerous adverse effects (AEs), including confusion, respiratory depression and even death, especially in pediatric and elderly patients. 5-8 Codeine is an opioid cough suppressant (antitussive) ... Other medications can affect the removal of guaifenesin/codeine from your body, which may affect how guaifenesin/codeine works.codeine. Used for Pain. Codeine is an opioid pain medication that's taken by mouth and used to treat mild-to-moderate pain. Common side effects of codeine include constipation, itching, sleepiness, and dizziness. It's typically not a first-choice pain medication because it can lead to more serious harm, such as slowed breathing and addiction.Codeine is an opioid cough suppressant (antitussive) ... Other medications can affect the removal of guaifenesin/codeine from your body, which may affect how guaifenesin/codeine works.Tell all of your health care providers and lab workers that you take Coditussin AC (guaifenesin and codeine). If you are 65 or older, use Coditussin AC (guaifenesin and codeine) with care. You could have more side effects. Different brands of Coditussin AC (guaifenesin and codeine) may have different doses for children.How to use Guaifenesin W/Codeine Syrup. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or ...Codeine es un antitusivo narcótico. Éste afecta las señales en el cerebro que provocan el reflejo de la tos. Guaifenesin es un expectorante. Éste ayuda a que la congestión se afloje en su pecho y garganta, haciendo más fácil toserla por la boca. Codeine and guaifenesin es una medicina combinada para tratar la tos y...Physical effects. Codeine taken at high doses could produce the following effects that can last 3-5 hours: drowsiness. headaches. slowed breathing. nausea and vomiting. smaller (constricted) pupils. feeling heavy in the arms and legs. severe itching or warm/hot sensation on the skin.Descriptions. Guaifenesin is used to help clear mucus or phlegm (pronounced flem) from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs. This medicine is available both over-the-counter (OTC) and with your doctor's prescription. Do not give any over-the-counter (OTC) cough and cold ...Codeine is an effective pain reliever; however, it is addictive, may cause constipation, and its pain-relieving effects vary markedly between individuals. Codeine should only be used for pain relief... View more. Prescription only. Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Jun 14, 2022 · codeine phosphate 10 MG / guaiFENesin 100 MG in 5 mL Oral Solution: PSN: 2: 995868: codeine phosphate 2 MG/ML / guaifenesin 20 MG/ML Oral Solution: SCD: 3: 995868: codeine phosphate 10 MG / guaifenesin 100 MG per 5 ML Oral Solution: SY For regular (short-acting) oral dosage forms (capsules, oral solution, syrup, or tablets): For cough: Adults—200 to 400 milligrams (mg) every four hours. Children 6 to 12 years of age—100 to 200 mg every four hours. Children 4 to 6 years of age—50 to 100 mg every four hours. Children and infants up to 4 years of age—Use is not recommended .Codeine is a medication used in the management and treatment of chronic pain. It is in the opioid class of medications. This activity outlines the indications, action, and contraindications for codeine as a valuable agent in treating chronic pain and off-label use in cough, persistent diarrhea, and restless leg syndrome. In addition, this activity will highlight the mechanism of action ...Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Guaifenesin is used to help clear mucus or phlegm from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs. This medicine is available only with your doctor's ...How to use Guaifenesin W/Codeine Syrup. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or ... How to use Guaifenesin W/Codeine Syrup. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or ... Codeine, guaifenesin, and pseudoephedrine is a combination medicine used to treat cough, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu. This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it.Find patient medical information for acetaminophen-codeine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.Codeine is also used to treat diarrhoea. It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress caused by pain. Codeine is available on prescription and comes as tablets, a liquid you swallow and as an injection. Codeine injections are usually only given in ...Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States.How to use Guaifenesin W/Codeine Syrup. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or ... If you are 65 or older, use G Tussin AC (guaifenesin and codeine) with care. You could have more side effects. Different brands of G Tussin AC (guaifenesin and codeine) may have different doses for children. Talk with the doctor before giving G Tussin AC (guaifenesin and codeine) to a child.Berikut adalah dosis umum codeine berdasarkan tujuan penggunaannya: Dewasa: Dosis awal 15–60 mg tiap 4 jam. Dosis maksimal 360 mg per hari. Anak usia di atas 12 tahun: 0,5–1 mg/kgBB, diberikan tiap 6 jam. Dosis maksimal 240 mg per hari dan dosis maksimal per dosis 60 mg. Dewasa: 15–30 mg 3–4 kali sehari.Guaifenesin, also known as glyceryl guaiacolate, is an expectorant medication taken by mouth and marketed as an aid to eliminate sputum from the respiratory tract. Chemically, it is an ether of guaiacol and glycerine. It may be used in combination with other medications. [3] alcohol while taking hydrocodone bitartrate and guaifenesin tablets because co-ingestion can result in fatal plasma hydrocodone levels. (5.8, 7.1) • Hydrocodone bitartrate and guaifenesin tablets is not recommended for use in pregnant women. Prolonged use of hydrocodone bitartrate and guaifenesin tablets during pregnancy can result in Generic Name (S): codeine-guaifenesin. This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal, breathing ... codeine/ guaifenesin liquid,oral possible synonyms: coditussin ac, dex-tuss, g tussin ac, gani-tuss nr, guaifenesin ac, guaifenesin-codeine, maxi-tuss ac, ninjacof-xg, tussiden cPhysical effects. Codeine taken at high doses could produce the following effects that can last 3-5 hours: drowsiness. headaches. slowed breathing. nausea and vomiting. smaller (constricted) pupils. feeling heavy in the arms and legs. severe itching or warm/hot sensation on the skin.Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Guaifenesin, also known as glyceryl guaiacolate, is an expectorant medication taken by mouth and marketed as an aid to eliminate sputum from the respiratory tract. Chemically, it is an ether of guaiacol and glycerine. It may be used in combination with other medications. [3] Typical dosing for Promethazine / codeine. Adults over 18 years old: The typical dose is 5 mL (1 teaspoonful) by mouth every 4 to 6 hours as needed. Do not take more than 30 mL (6 teaspoonfuls) in a day. Promethazine / codeine is not recommended for use in children under 18 years old.Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ...Codeine, guaifenesin, and pseudoephedrine is a combination medicine used to treat cough, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu. This medicine will not treat a cough that is caused by smoking, asthma, or emphysema. Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Aug 1, 2023 · Descriptions. Guaifenesin and hydrocodone combination is used to relieve cough and nasal congestion associated with the common cold. Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Guaifenesin is used to help clear mucus or phlegm from the chest when you have ... Initial dose: 15 to 60 mg orally up to every 4 hours as needed. Maximum dose: 360 mg in 24 hours. Comments: Initial doses should be individualized taking into account severity of pain, response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse. Doses higher than 60 mg have not been shown to improve pain ...Physical effects. Codeine taken at high doses could produce the following effects that can last 3-5 hours: drowsiness. headaches. slowed breathing. nausea and vomiting. smaller (constricted) pupils. feeling heavy in the arms and legs. severe itching or warm/hot sensation on the skin.Guaifenesin/codeine (Guaiatussin ac, cheratussin ac, virtussin ac) is an inexpensive drug used to treat cough. It is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic cheratussin ac is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.Codeine can cause serious unwanted effects if taken by adults, children, or pets who are not used to strong narcotic pain medicines. Make sure you store the medicine in a safe and secure place to prevent others from getting it. Drop off any unused narcotic medicine at a drug take-back location right away.2: IQVIA Report on Stimulant Trends from 2012 - 2021... hyperactive type 32 APPENDIX 6: SCHEDULE CONTROLLED SUBSTANCES CONSIDERED FOR ... J-max dhc 34380: Narc cgh/exp Guaifenesin-codeine Allfen cd 34380: Narc cgh/exp ... If you are 65 or older, use Guaifenesin AC Liquid (guaifenesin and codeine) with care. You could have more side effects. Different brands of Guaifenesin AC Liquid (guaifenesin and codeine) may have different doses for children. Talk with the doctor before giving Guaifenesin AC Liquid (guaifenesin and codeine) to a child.after a dosage increase. if you are older. if you have an existing lung problem. The side effects of codeine are similar to those of other opioids, and include: constipation. headache or dizziness. fatigue or drowsiness (especially soon after a dose) loss of appetite, nausea and vomiting. Always take medicines exactly as prescribed your doctor.Initial dose: 15 to 60 mg orally up to every 4 hours as needed. Maximum dose: 360 mg in 24 hours. Comments: Initial doses should be individualized taking into account severity of pain, response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse. Doses higher than 60 mg have not been shown to improve pain ...Codeine is also used to treat diarrhoea. It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress caused by pain. Codeine is available on prescription and comes as tablets, a liquid you swallow and as an injection. Codeine injections are usually only given in ...Codeine. Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is also commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. [3] [5] It is typically used to treat mild to moderate degrees of pain. [3]Find Guaifenesin coupons. Prices as low as $3.12, save up to 51.90% off the average retail price of $6.49 at pharmacies near you.codeine/ guaifenesin liquid,oral possible synonyms: coditussin ac, dex-tuss, g tussin ac, gani-tuss nr, guaifenesin ac, guaifenesin-codeine, maxi-tuss ac, ninjacof-xg, tussiden c CODEINE GUAIFENESIN- codeine phosphate, guaifenesin solution Leading Pharma, LLC. Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.-----Codeine and guaifenesin is a combination medicine used to treat cough and chest congestion caused by allergies, the common cold, or the flu. This medicine will not treat a cough that is caused...Robitussin Ac (guaifenesin with codeine) is a combination of an expectorant and a narcotic cough suppressant used to treat cough from the flu, cold, bronchitis, or sinusitis. Common side effects of Robitussin Ac include constipation, nausea, vomiting, sedation, low blood pressure on standing, irregular heartbeats, decreased urination, drowsiness, and headache. Consult your doctor if pregnant ... Guaifenesin is an expectorant that helps thin and loosen mucus in the lungs, making it easier to cough up the mucus. Codeine is an opioid cough suppressant (antitussive) that affects a certain part of the brain, reducing the urge to cough. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, Papaver somniferum (Papaveraceae). Codeine is utilized as a central ...Codeine is approved to treat pain and cough, and tramadol is approved to treat pain. These medicines carry serious risks, including slowed or difficult breathing and death, which appear to be a ...Jan 10, 2020 · CODEINE GUAIFENESIN- codeine phosphate, guaifenesin solution If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. NDC Sep 19, 2022 · If you are 65 or older, use G Tussin AC (guaifenesin and codeine) with care. You could have more side effects. Different brands of G Tussin AC (guaifenesin and codeine) may have different doses for children. Talk with the doctor before giving G Tussin AC (guaifenesin and codeine) to a child. How to use Guaifenesin W/Codeine Syrup. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or ... Dextromethorphan-guaifenesin 10-100 mg/5ml syrup Dextromethorphan-guaifenesin 10-200 mg/5ml liquid Diphenhydramine HCl 12.5 mg/5ml elixir Diphenhydramine HCl 12.5 mg/5ml liquid Guaifenesin 100 mg/5ml liquid Guaifenesin 100 mg/5ml syrup Guaifenesin-codeine 100-10 mg/5ml solution Loratadine 5 mg/5ml syrupA total of 486 drugs are known to interact with codeine / guaifenesin : 122 major drug interactions (477 brand and generic names) 361 moderate drug interactions (1496 brand and generic names) 3 minor drug interactions (7 brand and generic names) A total of 748 drugs are known to interact with codeine / promethazine : 181 major drug interactions ... Jan 10, 2020 · CODEINE GUAIFENESIN- codeine phosphate, guaifenesin solution If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. NDC Codeine is a medication used in the management and treatment of chronic pain. It is in the opioid class of medications. This activity outlines the indications, action, and contraindications for codeine as a valuable agent in treating chronic pain and off-label use in cough, persistent diarrhea, and restless leg syndrome. In addition, this activity will highlight the mechanism of action ...Feb 1, 2023 · headache. hives. nausea or vomiting. skin rash. stomach pain. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent. Common side effects include ...Guaifenesin and codeine phosphate is a drug prescribed for the treatment of cough caused by conditions such as the flu, cold, bronchitis, or sinusitis. Side effects, drug interactions, and dosage information should be reviewed prior to taking this medication.Brand names: Tuzistra XR, Lexuss 210, Z-Tuss AC, Zodryl AC, Tuxarin ER. Drug class: upper respiratory combinations. Chlorpheniramine/codeine systemic is used in the treatment of: Allergic Rhinitis. Cold Symptoms.Store at controlled room temperature 15°-30°C (59°-86°F). Cherry Flavor, Citric Acid, Glycerin,Masking flavor, Propylene glycol, Purified Water, Sodium Citrate, Sodium Benzoate, Sucralose Sorbitol. NDC 58657-500-16 - Codeine-Guaifenesin Oral Solution - 10-100 mg/5 mL - Antitussive - Expectorant - 16 fl. oz ...Tell all of your health care providers and lab workers that you take Ninjacof-XG (guaifenesin and codeine). If you are 65 or older, use Ninjacof-XG (guaifenesin and codeine) with care. You could have more side effects. Different brands of Ninjacof-XG (guaifenesin and codeine) may have different doses for children.codeine/ guaifenesin liquid,oral possible synonyms: coditussin ac, dex-tuss, g tussin ac, gani-tuss nr, guaifenesin ac, guaifenesin-codeine, maxi-tuss ac, ninjacof-xg, tussiden c Codeine and guaifenesin is a combination medicine used to treat cough and chest congestion caused by allergies, the common cold, or the flu. This medicine will not treat a cough that is caused by smoking, asthma, or emphysema. Codeine and guaifenesin may also be used for purposes not listed in this medication guide. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of guaifenesin, pseudoephedrine, and codeine can lead to overdose and death. If you have questions, talk with your doctor. This medicine has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs ...Active ingredients (in each 5 mL = 1 tsp) Purpose. Codeine phosphate, USP 10 mg. Antitussive. Guaifenesin, USP 100 mg. Expectorant. Uses. temporarily relieves: cough due to minor throat and bronchial irritation as may occur with a cold or inhaled irritants - your cough to help you sleep - helps loosen phlegm (mucus) and thin bronchial ...Sep 19, 2022 · If you are 65 or older, use G Tussin AC (guaifenesin and codeine) with care. You could have more side effects. Different brands of G Tussin AC (guaifenesin and codeine) may have different doses for children. Talk with the doctor before giving G Tussin AC (guaifenesin and codeine) to a child. FDA is restricting the use of codeine and tramadol medicines in children. Codeine is approved to treat pain and cough, and tramadol is approved to treat pain. These medicines carry serious risks ... Apr 19, 2023 · FDA approved a REMS for codeine to ensure that the benefits outweigh the risk. ... Tylenol, benzonatate, Benadryl, diphenhydramine, guaifenesin. Images. Codeine ... Jul 24, 2023 · What is Guaiatussin AC? Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
codeine/ guaifenesin liquid,oral possible synonyms: coditussin ac, dex-tuss, g tussin ac, gani-tuss nr, guaifenesin ac, guaifenesin-codeine, maxi-tuss ac, ninjacof-xg, tussiden c. 917 703 1456
Common codeine side effects include: feeling dizzy or drowsy; nausea, vomiting, stomach pain; constipation; sweating; or. mild itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.If you are 65 or older, use G Tussin AC (guaifenesin and codeine) with care. You could have more side effects. Different brands of G Tussin AC (guaifenesin and codeine) may have different doses for children. Talk with the doctor before giving G Tussin AC (guaifenesin and codeine) to a child.Official Label (Printer Friendly) View All Sections. Active ingredients (in each 5 mL teaspoonful) Codeine Phosphate, USP 10 mg - Guaifenesin, USP 100 mg. Codeine Phosphate, USP 10 mg. Guaifenesin, USP 100 mg. Close. Purposes. Cough Suppressant - Expectorant.Codeine es un antitusivo narcótico. Éste afecta las señales en el cerebro que provocan el reflejo de la tos. Guaifenesin es un expectorante. Éste ayuda a que la congestión se afloje en su pecho y garganta, haciendo más fácil toserla por la boca. Codeine and guaifenesin es una medicina combinada para tratar la tos y... Initial dose: 15 to 60 mg orally up to every 4 hours as needed. Maximum dose: 360 mg in 24 hours. Comments: Initial doses should be individualized taking into account severity of pain, response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse. Doses higher than 60 mg have not been shown to improve pain ...Generic Name (S): codeine-guaifenesin. This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal, breathing ...Jan 10, 2023 · Active ingredients (in each 5 mL = 1 tsp) Purpose. Codeine phosphate, USP 10 mg. Antitussive. Guaifenesin, USP 100 mg. Expectorant. Uses. temporarily relieves: cough due to minor throat and bronchial irritation as may occur with a cold or inhaled irritants - your cough to help you sleep - helps loosen phlegm (mucus) and thin bronchial ... Active ingredients (in each 5 mL = 1 tsp) Purpose. Codeine phosphate, USP 10 mg. Antitussive. Guaifenesin, USP 100 mg. Expectorant. Uses. temporarily relieves: cough due to minor throat and bronchial irritation as may occur with a cold or inhaled irritants - your cough to help you sleep - helps loosen phlegm (mucus) and thin bronchial ...Feb 1, 2023 · headache. hives. nausea or vomiting. skin rash. stomach pain. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Mar 27, 2023 · Indications and Usage for Codeine Phosphate and Guaifenesin. · temporarily relieves these symptoms due to the common cold: · cough due to minor throat and bronchial irritation. · helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive. Jun 1, 2023 · Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Guaifenesin is used to help clear mucus or phlegm from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs. Guaifenesin (Oral Route) Merative, Micromedex. Guaifenesin is used to help clear mucus or phlegm (pronounced flem) from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs. This medicine is available both over-the-counter (OTC) and with your doctor's prescription.A total of 486 drugs are known to interact with codeine / guaifenesin : 122 major drug interactions (477 brand and generic names) 361 moderate drug interactions (1496 brand and generic names) 3 minor drug interactions (7 brand and generic names) A total of 748 drugs are known to interact with codeine / promethazine : 181 major drug interactions ... .
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